What is a correct statement regarding the relationship between an institution and its IRB(s)?

The correct statement regarding the relationship between an institution and its IRB(s) is that officials of the institution may overrule IRB approval. This reflects the regulatory framework that allows institutional officials to consider the broader implications of a study, particularly in relation to institutional policies, resource availability, or potential risks to the institution's reputation. While the IRB is responsible for ensuring the ethical review of research protocols according to federal regulations and ethical standards, the institution maintains ultimate oversight and authority over the research activities conducted within its purview. Therefore, a research project that has received IRB approval could still be blocked by institutional officials if there are significant concerns that the IRB may not have addressed, such as funding issues or conflicting institutional priorities.

In contrast, the other statements suggest misunderstandings about the roles and governance structures regarding IRBs within institutions. For example, implying that IRB approval cannot be overruled doesn't accommodate the institution's authority or the necessity for alignment with its regulations and policies. Similarly, stating that IRB decisions are final and non-negotiable overlooks the point that institutions can and do have mechanisms to review and potentially challenge these decisions in the context of the institution’s overall risk management and ethical compliance responsibilities. Lastly, the claim that institutions have